×
Entrez Id: 338
Gene Symbol: APOB
APOB
0.700
Biomarker
disease
RGD
The influence of pharmacogenetics on fatty liver disease in the wistar and kyoto rats: a combined transcriptomic and metabonomic study.
17203948 2007
×
Entrez Id: 5465
Gene Symbol: PPARA
PPARA
0.600
Biomarker
disease
RGD
Peroxisome proliferator-activated receptor-alpha and -gamma mRNA levels are reduced in chronic hepatitis C with steatosis and genotype 3 infection.
16393287 2006
×
Entrez Id: 1571
Gene Symbol: CYP2E1
CYP2E1
0.550
Biomarker
disease
RGD
Beneficial effects of Vitis coignetiae Pulliat leaves on nonalcoholic steatohepatitis in a rat model.
19404342 2009
×
Entrez Id: 7351
Gene Symbol: UCP2
UCP2
0.540
Biomarker
disease
RGD
The effect of rat strain, diet composition and feeding period on the development of a nutritional model of non-alcoholic fatty liver disease in rats.
21114362 2011
×
Entrez Id: 5728
Gene Symbol: PTEN
PTEN
0.520
Biomarker
disease
RGD
PTEN down-regulation by unsaturated fatty acids triggers hepatic steatosis via an NF-kappaBp65/mTOR-dependent mechanism.
18166358 2008
×
Entrez Id: 847
Gene Symbol: CAT
CAT
0.510
Biomarker
disease
RGD
Black tea prevents high fat diet-induced non-alcoholic steatohepatitis.
21452373 2011
×
Entrez Id: 5468
Gene Symbol: PPARG
PPARG
0.400
Biomarker
disease
RGD
Peroxisome proliferator activated receptor-gamma in pathogenesis of experimental fatty liver disease.
15112352 2004
×
Entrez Id: 348
Gene Symbol: APOE
APOE
0.400
Biomarker
disease
RGD
Hyperlipidemia induces typical atherosclerosis development in Ldlr and Apoe deficient rats.
29459263 2018
×
Entrez Id: 9370
Gene Symbol: ADIPOQ
ADIPOQ
0.300
Biomarker
disease
RGD
Adiponectin and its receptors in rodent models of fatty liver disease and liver cirrhosis.
17006986 2006
×
Entrez Id: 3569
Gene Symbol: IL6
IL6
0.270
Biomarker
disease
RGD
Fosinopril significantly reduced the degree of hepatic steatosis , serum FG, insulin, ALT, TNF-alpha and IL-6 concentrations and hepatic TNF-alpha and IL-6 mRNA expression.
19076162 2009
PPARGC1A
0.260
Therapeutic
disease
RGD
Hepatic lipid metabolic pathways modified by resveratrol in rats fed an obesogenic diet.
23274094 2013
PPARGC1A
0.260
Biomarker
disease
RGD
The liver steatosis resulted predominantly from hypomethylation of PGC1 -α, decreased binding with its partners and subsequent impaired mitochondrial fatty acid oxidation.
22521344 2012
×
Entrez Id: 3643
Gene Symbol: INSR
INSR
0.250
Therapeutic
disease
RGD
Liver-specific insulin receptor isoform A expression enhances hepatic glucose uptake and ameliorates liver steatosis in a mouse model of diet-induced obesity.
30642871 2019
×
Entrez Id: 84649
Gene Symbol: DGAT2
DGAT2
0.250
Therapeutic
disease
RGD
Suppression of diacylglycerol acyltransferase-2 (DGAT2 ), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance.
17526931 2007
×
Entrez Id: 3643
Gene Symbol: INSR
INSR
0.250
Therapeutic
disease
RGD
Extracts from Salvia-Nelumbinis naturalis alleviate hepatosteatosis via improving hepatic insulin sensitivity.
25160038 2014
×
Entrez Id: 3643
Gene Symbol: INSR
INSR
0.250
Biomarker
disease
RGD
Multiple factors and pathways involved in hepatic very low density lipoprotein-apoB100 overproduction in Otsuka Long-Evans Tokushima Fatty rats.
22546076 2012
×
Entrez Id: 2538
Gene Symbol: G6PC
G6PC
0.230
Biomarker
disease
RGD
Saccharin Increases Fasting Blood Glucose but Not Liver Insulin Resistance in Comparison to a High Fructose-Fed Rat Model.
29534506 2018
×
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
0.230
Biomarker
disease
RGD
Celecoxib attenuates liver steatosis and inflammation in non-alcoholic steatohepatitis induced by high-fat diet in rats.
21643627 2011
×
Entrez Id: 3586
Gene Symbol: IL10
IL10
0.230
Biomarker
disease
RGD
Interleukin-10 is a protective factor against diet-induced insulin resistance in liver.
18267346 2008
×
Entrez Id: 3638
Gene Symbol: INSIG1
INSIG1
0.230
Biomarker
disease
RGD
The mRNA of endogenous insig-1 , but not -2a and -2b, was higher in the fatty livers of untreated obese ZDF (fa/fa) rats compared with controls, but the elevation was not sufficient to block the approximately 3-fold increase in SREBP-1c expression and activity.
15096598 2004
×
Entrez Id: 3553
Gene Symbol: IL1B
IL1B
0.220
Biomarker
disease
RGD
Rosiglitazone attenuates liver inflammation in a rat model of nonalcoholic steatohepatitis.
17436085 2007
×
Entrez Id: 3606
Gene Symbol: IL18
IL18
0.220
Biomarker
disease
RGD
Inhibition of hepatic interleukin-18 production by rosiglitazone in a rat model of nonalcoholic fatty liver disease.
19084941 2008
×
Entrez Id: 2645
Gene Symbol: GCK
GCK
0.220
Biomarker
disease
RGD
Small molecule glucokinase activators disturb lipid homeostasis and induce fatty liver in rodents: a warning for therapeutic applications in humans.
22925001 2013
×
Entrez Id: 19
Gene Symbol: ABCA1
ABCA1
0.220
Biomarker
disease
RGD
Soy protein reduces hepatic lipotoxicity in hyperinsulinemic obese Zucker fa/fa rats.
15995177 2005
×
Entrez Id: 3598
Gene Symbol: IL13RA2
IL13RA2
0.210
Biomarker
disease
RGD
We report that hepatic stellate cells (HSC) in sinusoidal lesions of liver of patients with NASH express high levels of high-affinity IL-13R (IL-13Ralpha2 ), which is colocalized with smooth muscle actin, whereas fatty liver and normal liver specimens do not express IL-13Ralpha2 .
18802068 2008